Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …

Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …

Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct
phenotypic and genetic characteristics of the original tissue and are useful for research on …

Organoids/organs-on-a-chip open up new frontiers for basic and clinical research of
intestinal diseases. Species-specific differences hinder research on animal models, while …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial
permeability and intestinal inflammation to assess probiotic intervention as live …

The intestinal tract is a vital organ responsible for digestion and absorption in the human
body and plays an essential role in pathogen invasion. Compared with other traditional …

Microfluidic technologies have been extensively investigated in recent years for developing
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …

The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …

Disruption of the intestinal epithelial barrier is a hallmark of mucosal inflammation. It
increases exposure of the immune system to luminal microbes, triggering a perpetuating …