Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently
discovered class of glycosylated molecules, because of a lack of visualization methods. We …

Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …

Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

The hallmarks of cancer are characterized by functional capabilities that allow cancer cells
to survive, proliferate and disseminate during the multistep tumorigenesis. Cancer being a …

Glycosylation is one of the most prevalent posttranslational modifications that profoundly
affects the structure and functions of proteins in a wide variety of biological recognition …

The Hippo pathway is crucial in organ size control and tissue homeostasis, with
deregulation leading to cancer. An extracellular nutrition signal, such as glucose, regulates …

Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate
multi-step process that requires the acquisition of several cancer cell features, including the …