The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …

The function of sperm is to safely transport the haploid paternal genome to the egg
containing the maternal genome. The subsequent fertilization leads to transmission of a new …

We report the identification of 67 previously undescribed histone modifications, increasing
the current number of known histone marks by about 70%. We further investigated one of the …

We report the identification of a new type of histone mark, lysine 2-hydroxyisobutyrylation
(Khib), and identify the mark at 63 human and mouse histone Khib sites, including 27 unique …

Abstract Cancer/testis (CT) antigens, of which more than 40 have now been identified, are
encoded by genes that are normally expressed only in the human germ line, but are also …

In mammals, male germ cells differentiate from haploid round spermatids to flagella-
containing motile sperm, in a process called spermiogenesis. This process is distinct from …

Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with
active transcription in mammalian cells. Here we report that the chromodomain Y-like …

Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a
distinct morphological change, and the protamines replace the core histones to facilitate …

Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …

Repetitive-element-derived Piwi-interacting RNAs (piRNAs), act together with Piwi proteins
Mili (also known as Piwil2) and Miwi2 (also known as Piwil4) in a genome defence …