The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Abstract E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial
sheets. Through the homophilic association of E-Cadherin molecules expressed on …

The microtubule (MT) cytoskeleton plays an essential role in mitosis, intracellular transport,
cell shape, and cell migration. The assembly and disassembly of MTs, which can occur …

Cadherins and integrins are intrinsically linked through the actin cytoskeleton and are
largely responsible for the mechanical integrity and organization of tissues. We show that …

The cytoskeleton is crucially important for the assembly of cell-cell junctions and the
homeostatic regulation of their functions. Junctional proteins act, in turn, as anchors for …

Rationale: Loss-of-function of the cardiac sodium channel NaV1. 5 causes conduction
slowing and arrhythmias. NaV1. 5 is differentially distributed within subcellular domains of …

Mechanisms by which microtubule plus ends interact with regions of cell–cell contact during
tissue development and morphogenesis are not fully understood. We characterize a …

Tissues of multicellular organisms are characterised by several types of specialised cell–cell
junctions. In vertebrate epithelia and endothelia, tight and adherens junctions (AJ) play …

Staphylococcus aureus is a major etiological agent of sepsis and induces endothelial cell
(EC) barrier dysfunction and inflammation, two major hallmarks of acute lung injury …