Bariatric surgery constitutes an approach to the management of obesity in which the
anatomy of the gastrointestinal tract is altered to reduce access of nutrients to absorptive …

Opioid use disorder (OUD) is a major public health problem. High relapse rates and poor
treatment retention continue to pose major challenges in OUD treatment. Of the abused …

The pharmacokinetics of propranolol were investigated in obese and healthy weight groups.
Research studies in relation to the presented topic were gathered, evaluated, and compared …

Calorie restriction (CR) extends lifespan and increases resistance to multiple forms of stress,
including renal ischemia‐reperfusion (I/R) injury. However, whether CR has protective …

In many comparative trials examining the effects of adult obesity on pharmacokinetics of
drugs, conclusions were made based on values that were either not adjusted to total body …

Objectives Rectus sheath blocks are an established option for analgesia following
abdominal surgery, but pharmacokinetic data are limited. This study sought to characterise …

Aim: To develop stable paclitaxel (PTX)-loaded bovine serum albumin (BSA) nanoparticles
(BSA-NPs-PTX) as drug-delivery vehicles for delivering paclitaxel into the brain to treat …

Aim: Vanillin used as a positive control substrate of aldehyde oxidase activity gets
metabolized to vanillic acid. Low MW and low sensitivity in negative ion mode are …

Background: Warfarin is a widely used racemic anticoagulant with narrow therapeutic range
and wide interindividual response to treatment. This is due to the extensive and differential …

Background: We have demonstrated the use of a single-point calibration approach, derived
from in vitro metabolite identification studies utilizing radiolabeled imipramine, that allows for …