Retrosynthetic design of metabolic pathways to chemicals not found in nature
Biology produces a universe of chemicals whose precision and complexity is the envy of
chemists. Over the last 30 years, the expansive field of metabolic engineering has many …
chemists. Over the last 30 years, the expansive field of metabolic engineering has many …
A review of computational tools for design and reconstruction of metabolic pathways
Metabolic pathways reflect an organism's chemical repertoire and hence their elucidation
and design have been a primary goal in metabolic engineering. Various computational …
and design have been a primary goal in metabolic engineering. Various computational …
White biotechnology: state of the art strategies for the development of biocatalysts for biorefining
S Heux, I Meynial-Salles, MJ O'Donohue… - Biotechnology …, 2015 - Elsevier
White biotechnology is a term that is now often used to describe the implementation of
biotechnology in the industrial sphere. Biocatalysts (enzymes and microorganisms) are the …
biotechnology in the industrial sphere. Biocatalysts (enzymes and microorganisms) are the …
Automated engineering of synthetic metabolic pathways for efficient biomanufacturing
I Otero-Muras, P Carbonell - Metabolic Engineering, 2021 - Elsevier
Metabolic engineering involves the engineering and optimization of processes from single-
cell to fermentation in order to increase production of valuable chemicals for health, food …
cell to fermentation in order to increase production of valuable chemicals for health, food …
Unravelling formaldehyde metabolism in bacteria: road towards synthetic methylotrophy
Formaldehyde metabolism is prevalent in all organisms, where the accumulation of
formaldehyde can be prevented through the activity of dissimilation pathways. Furthermore …
formaldehyde can be prevented through the activity of dissimilation pathways. Furthermore …
Methanol dehydrogenases as a key biocatalysts for synthetic methylotrophy
TK Le, YJ Lee, GH Han, SJ Yeom - Frontiers in Bioengineering and …, 2021 - frontiersin.org
One-carbon (C1) chemicals are potential building blocks for cheap and sustainable re-
sources such as methane, methanol, formaldehyde, formate, carbon monoxide, and more …
sources such as methane, methanol, formaldehyde, formate, carbon monoxide, and more …
Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle
Covering: 2000 to 2016 Progress in synthetic biology is enabled by powerful bioinformatics
tools allowing the integration of the design, build and test stages of the biological …
tools allowing the integration of the design, build and test stages of the biological …
Designing overall stoichiometric conversions and intervening metabolic reactions
A Chowdhury, CD Maranas - Scientific reports, 2015 - nature.com
Existing computational tools for de novo metabolic pathway assembly, either based on
mixed integer linear programming techniques or graph-search applications, generally only …
mixed integer linear programming techniques or graph-search applications, generally only …
Computational approaches to design and test plant synthetic metabolic pathways
A Küken, Z Nikoloski - Plant Physiology, 2019 - academic.oup.com
Successfully designed and implemented plant-specific synthetic metabolic pathways hold
promise to increase crop yield and nutritional value. Advances in synthetic biology have …
promise to increase crop yield and nutritional value. Advances in synthetic biology have …
Enumerating all possible biosynthetic pathways in metabolic networks
Exhaustive identification of all possible alternate pathways that exist in metabolic networks
can provide valuable insights into cellular metabolism. With the growing number of …
can provide valuable insights into cellular metabolism. With the growing number of …