Advances in preclinical research models of radiation-induced cardiac toxicity

RA Schlaak, G SenthilKumar, M Boerma, C Bergom - Cancers, 2020 - mdpi.com
Radiation therapy (RT) is an important component of cancer therapy, with> 50% of cancer
patients receiving RT. As the number of cancer survivors increases, the short-and long-term …

Rapid recruitment and IFN-I–mediated activation of monocytes dictate focal radiotherapy efficacy

S Tadepalli, DR Clements, S Saravanan… - Science …, 2023 - science.org
The recruitment of monocytes and their differentiation into immunosuppressive cells is
associated with the low efficacy of preclinical nonconformal radiotherapy (RT) for tumors …

Design optimization of an electron-to-photon conversion target for ultra-high dose rate x-ray (FLASH) experiments at TRIUMF

N Esplen, L Egoriti, B Paley, T Planche… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. To develop a bremsstrahlung target and megavoltage (MV) x-ray irradiation
platform for ultrahigh dose-rate (UHDR) irradiation of small-animals on the Advanced Rare …

Monte Carlo simulations of EBT3 film dose deposition for percentage depth dose (PDD) curve evaluation

SM Robinson, N Esplen, D Wells… - Journal of Applied …, 2020 - Wiley Online Library
Abstract Purpose To use Monte Carlo (MC) calculations to evaluate the effects of Gafchromic
EBT3 film orientation on percentage depth dose (PDD) curves. Methods Dose deposition in …

Current instrumentation and technologies in modern radiobiology research—opportunities and challenges

E Ford, J Deye - Seminars in radiation oncology, 2016 - Elsevier
There is a growing awareness of the gaps in the technical methods employed in radiation
biology experiments. These quality gaps can have a substantial effect on the reliability and …

Impact of backscatter material thickness on the depth dose of orthovoltage irradiators for radiobiology research

Q Chen, J Molloy, T Izumi… - Physics in Medicine & …, 2019 - iopscience.iop.org
The orthovoltage x-ray energy frequently used in radiation research is prone to dosimetry
errors due to insufficient backscatter conditions. In many radiobiology studies, especially for …

A framework for inverse planning of beam-on times for 3D small animal radiotherapy using interactive multi-objective optimisation

M Balvert, SJ van Hoof, PV Granton… - Physics in Medicine …, 2015 - iopscience.iop.org
Advances in precision small animal radiotherapy hardware enable the delivery of
increasingly complicated dose distributions on the millimeter scale. Manual creation and …

A kernel-based dose calculation algorithm for kV photon beams with explicit handling of energy and material dependencies

AM Reinhart, MF Fast, P Ziegenhein… - The British journal of …, 2017 - academic.oup.com
Objective: Mimicking state-of-the-art patient radiotherapy with high-precision irradiators for
small animals is expected to advance the understanding of dose–effect relationships and …

Scattered dose calculations and measurements in a life-like mouse phantom

D Welch, L Turner, M Speiser… - Radiation …, 2017 - meridian.allenpress.com
Anatomically accurate phantoms are useful tools for radiation dosimetry studies. In this work,
we demonstrate the construction of a new generation of life-like mouse phantoms in which …

18F-EF5 PET Is Predictive of Response to Fractionated Radiotherapy in Preclinical Tumor Models

R Ali, S Apte, M Vilalta, M Subbarayan, Z Miao… - PLoS …, 2015 - journals.plos.org
We evaluated the relationship between pre-treatment positron emission tomography (PET)
using the hypoxic tracer 18F-[2-(2-nitro-1-H-imidazol-1-yl)-N-(2, 2, 3, 3, 3-pentafluoropropyl) …