Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory
response in mammals. Due to these roles in inflammation, plasminogen has been …

Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease
characterised by unregulated proteolytic destruction of lung tissue mediated via a protease …

Summary Plasminogen activator inhibitor‐1 (PAI‐1, also known as SERPINE 1) is a member
of the serine protease inhibitor (SERPIN) superfamily and is the primary physiological …

Supplemental O2 (hyperoxia; 30–90% O2) is a necessary intervention for premature infants,
but it contributes to development of neonatal and pediatric asthma, necessitating better …

Background Eosinophilic esophagitis (EoE) is an allergic disease of increasing worldwide
incidence. Complications are due to tissue remodeling and involve TGF-β1–mediated …

Lung function, strongly associated with morbidity and mortality, decreases with age. This
study examines whether poor adult lung function is associated with age accelerations (AAs) …

Fibrosis is a prevalent pathological condition arising from the chronic activation of
fibroblasts. This activation results from the extensive intercellular crosstalk mediated by both …

Background Asthma and obesity are both complex conditions characterized by chronic
inflammation, and obesity-related severe asthma has been associated with differences in …

Background Epidemiologic studies have shown that asthmatic patients, in particular those
with severe disease, have increased risk of pulmonary embolism. It is unknown whether …

Contributions of mechanical signals to airway remodeling during asthma are poorly
understood. Transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion …