Calcium ion (Ca 2+) is a ubiquitous and versatile signaling molecule controlling a wide
variety of cellular processes, such as proliferation, cell death, migration, and immune …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It
has a poor response to conventional therapy and has an extremely poor 5-year survival rate …

Pancreatic cancer (PC) represents a group of malignant tumours originating from pancreatic
duct epithelial cells and acinar cells, and the 5-year survival rate of PC patients is only …

Simple Summary Cancer, which is a major health problem, is a complex disease. Currently,
the main treatment methods are surgery, chemotherapy, radiotherapy and biological …

Simple Summary Novel pharmacological approaches are needed to improve treatments of
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …

The role of T-type calcium channels is well established in excitable cells, where they preside
over action potential generation, automaticity, and firing. They also contribute to intracellular …

Gastrointestinal (GI) cancers continue to be a major cause of mortality and morbidity
globally. Understanding the molecular pathways associated with cancer progression and …

Gemcitabine resistance is a major obstacle to the effectiveness of chemotherapy in
pancreatic ductal adenocarcinoma (PDAC). Therefore, new strategies are needed to …

Pancreatic cancer (PC), a disease with high heterogeneity and a dense stromal
microenvironment, presents significant challenges and a bleak prognosis. Recent …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, primarily
due to intrinsic or acquired resistance to chemotherapy, such as Gemcitabine (Gem) …