Background: Dolutegravir (DTG)-based antiretroviral therapy (ART) rarely leads to
virological failure (VF) and drug resistance in integrase strand transfer inhibitor (INSTI)-naïve …

Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line
treatment of human immunodeficiency virus type one (HIV-1) infection. The first-generation …

Background The widespread use of the integrase strand transfer inhibitor (INSTI)
dolutegravir in first-line and second-line antiretroviral therapy (ART) might facilitate …

Cabotegravir (CAB) is an integrase strand transfer inhibitor (INSTI) formulated as a long-
acting injectable drug approved for pre-exposure prophylaxis and use with a long acting …

Background: Integrase strand-transfer inhibitor (INSTI)-containing regimens have gradually
been administered in Guangdong Province, China beginning in 2016, and INSTI-related …

Integrase strand transfer inhibitors (INSTIs), in combination with other antivirals, are widely
used for the treatment of HIV-1-infected individuals. HIV-1 resistance to INSTIs is typically …

Background: The widespread use of the integrase strand transfer inhibitor (INSTI)
dolutegravir (DTG) in first-and second-line antiretroviral therapy (ART) may facilitate …

After a decade of dolutegravir (DTG) use in various antiretroviral therapy combinations and
in diverse populations globally, it is critical to identify HIV strains with reduced drug …

Introduction The clinical development of antiretroviral drugs has been followed by a rapid
and concomitant development of HIV drug resistance. The development and spread of HIV …

Viral drug resistance is an everlasting topic for HIV/AIDS professionals from clinical,
laboratory and public health perspectives [1]. As one of the most challenging human viral …