Deubiquitinases: From mechanisms to their inhibition by small molecules
Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …
Resolving the complexity of ubiquitin networks
Ubiquitination regulates nearly all cellular processes by coordinated activity of ubiquitin
writers (E1, E2, and E3 enzymes), erasers (deubiquitinating enzymes) and readers (proteins …
writers (E1, E2, and E3 enzymes), erasers (deubiquitinating enzymes) and readers (proteins …
BioE3 identifies specific substrates of ubiquitin E3 ligases
O Barroso-Gomila, L Merino-Cacho, V Muratore… - Nature …, 2023 - nature.com
Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification
by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a …
by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a …
[HTML][HTML] MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes
SAA Rehman, YA Kristariyanto, SY Choi, PJ Nkosi… - Molecular cell, 2016 - cell.com
Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to
regulate the functional outcome of ubiquitylation. Here we report the discovery of a new …
regulate the functional outcome of ubiquitylation. Here we report the discovery of a new …
Discovery and characterization of ZUFSP/ZUP1, a distinct deubiquitinase class important for genome stability
Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we
report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal …
report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal …
[HTML][HTML] Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase
M Fottner, AD Brunner, V Bittl, D Horn-Ghetko… - Nature chemical …, 2019 - nature.com
Post-translational modification of proteins with ubiquitin and ubiquitin-like proteins (Ubls) is
central to the regulation of eukaryotic cellular processes. Our ability to study the effects of …
central to the regulation of eukaryotic cellular processes. Our ability to study the effects of …
Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair
DA Reid, S Keegan, A Leo-Macias… - Proceedings of the …, 2015 - National Acad Sciences
Nonhomologous end-joining (NHEJ) is a major repair pathway for DNA double-strand
breaks (DSBs), involving synapsis and ligation of the broken strands. We describe the use of …
breaks (DSBs), involving synapsis and ligation of the broken strands. We describe the use of …
Systems‐wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation
B‐cell receptor (BCR) signaling is essential for the development and function of B cells;
however, the spectrum of proteins involved in BCR signaling is not fully known. Here we …
however, the spectrum of proteins involved in BCR signaling is not fully known. Here we …
Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction
EH Abdelkader, H Qianzhu, J George… - Angewandte …, 2022 - Wiley Online Library
Cyanopyridylalanines are non‐canonical amino acids that react with aminothiol compounds
under physiological conditions in a biocompatible manner without requiring added catalyst …
under physiological conditions in a biocompatible manner without requiring added catalyst …
UBE2N promotes melanoma growth via MEK/FRA1/SOX10 signaling
Abstract UBE2N is a K63-specific ubiquitin conjugase linked to various immune disorders
and cancer. Here, we demonstrate that UBE2N and its partners UBE2V1 and UBE2V2 are …
and cancer. Here, we demonstrate that UBE2N and its partners UBE2V1 and UBE2V2 are …