Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading
to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2 …

The jumonji (JMJ) family of histone demethylases are Fe2+-and α-ketoglutarate-dependent
oxygenases that are essential components of regulatory transcriptional chromatin …

Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to R
(−)‐2‐hydroxyglutarate (R‐2HG) accumulation. By using biochemical, structural and cellular …

Modulating chromatin through histone methylation orchestrates numerous cellular
processes. SETD2-dependent trimethylation of histone H3K36 is associated with active …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

INTRODUCTION Natural posttranslational modifications (PTMs) to proteins expand the
chemical groups available to proteins. The ability to expand posttranslational functional …

Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic
transcription. Jumonji C domain–containing histone demethylases (JMJs) dynamically …

Lysine methylation is one of the most prominent histone posttranslational modifications that
regulate chromatin structure. Changes in histone lysine methylation status have been …