Innovations and advances in modelling and measuring pain in animals
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …
decade as a result of technological advancements, the continued dearth of translational …
Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section
Intervertebral disc degeneration is strongly associated with chronic low back pain, a leading
cause of disability worldwide. Current back pain treatment approaches (both surgical and …
cause of disability worldwide. Current back pain treatment approaches (both surgical and …
[HTML][HTML] Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain
Back pain is the# 1 cause of years lived with disability worldwide, yet surprisingly little is
known regarding the biology underlying this symptom. We conducted a genome-wide …
known regarding the biology underlying this symptom. We conducted a genome-wide …
Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats
W Jiang, JD Glaeser, G Kaneda, J Sheyn… - Science Translational …, 2023 - science.org
Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research
M Zhou, AA Theologis, GD O'Connell - JOR spine, 2024 - Wiley Online Library
Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss,
and disability, is a common musculoskeletal disorder that results in significant …
and disability, is a common musculoskeletal disorder that results in significant …
A comprehensive tool box for large animal studies of intervertebral disc degeneration
NN Lee, E Salzer, FC Bach, AF Bonilla, JL Cook… - JOR …, 2021 - Wiley Online Library
Preclinical studies involving large animal models aim to recapitulate the clinical situation as
much as possible and bridge the gap from benchtop to bedside. To date, studies …
much as possible and bridge the gap from benchtop to bedside. To date, studies …
Nanofibrous spongy microspheres to deliver rabbit mesenchymal stem cells and anti-miR-199a to regenerate nucleus pulposus and prevent calcification
Lower back pain is mainly caused by intervertebral disc degeneration, in which calcification
is frequently involved. Here novel nanofibrous spongy microspheres (NF-SMS) are used to …
is frequently involved. Here novel nanofibrous spongy microspheres (NF-SMS) are used to …
Growing a backbone–functional biomaterials and structures for intervertebral disc (ivd) repair and regeneration: challenges, innovations, and future directions
MD Harmon, DM Ramos, D Nithyadevi, R Bordett… - Biomaterials …, 2020 - pubs.rsc.org
Back pain and associated maladies can account for an immense amount of healthcare cost
and loss of productivity in the workplace. In particular, spine related injuries in the US affect …
and loss of productivity in the workplace. In particular, spine related injuries in the US affect …
Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical
AA Thorpe, FC Bach, MA Tryfonidou, CL Le Maitre… - JOR …, 2018 - Wiley Online Library
Chronic back and neck pain is a prevalent disability, often caused by degeneration of the
intervertebral disc. Because current treatments for this condition are less than satisfactory, a …
intervertebral disc. Because current treatments for this condition are less than satisfactory, a …
[HTML][HTML] Interleukin-8 as a therapeutic target for chronic low back pain: upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in …
E Krock, M Millecamps, KM Anderson, A Srivastava… - …, 2019 - thelancet.com
Background Low back pain (LBP) is the leading global cause of disability and is associated
with intervertebral disc degeneration (DD) in some individuals. However, many adults have …
with intervertebral disc degeneration (DD) in some individuals. However, many adults have …