Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Intervertebral disc degeneration is strongly associated with chronic low back pain, a leading
cause of disability worldwide. Current back pain treatment approaches (both surgical and …

Back pain is the# 1 cause of years lived with disability worldwide, yet surprisingly little is
known regarding the biology underlying this symptom. We conducted a genome-wide …

Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …

Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss,
and disability, is a common musculoskeletal disorder that results in significant …

Preclinical studies involving large animal models aim to recapitulate the clinical situation as
much as possible and bridge the gap from benchtop to bedside. To date, studies …

Lower back pain is mainly caused by intervertebral disc degeneration, in which calcification
is frequently involved. Here novel nanofibrous spongy microspheres (NF-SMS) are used to …

Back pain and associated maladies can account for an immense amount of healthcare cost
and loss of productivity in the workplace. In particular, spine related injuries in the US affect …

Chronic back and neck pain is a prevalent disability, often caused by degeneration of the
intervertebral disc. Because current treatments for this condition are less than satisfactory, a …

Background Low back pain (LBP) is the leading global cause of disability and is associated
with intervertebral disc degeneration (DD) in some individuals. However, many adults have …