[HTML][HTML] Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases

A Fallah, A Sadeghinia, H Kahroba, A Samadi… - Biomedicine & …, 2019 - Elsevier
Angiogenesis is a critical step in the progression of almost all human malignancies and
some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective …

The regulatory role of micro RNA s in angiogenesis‐related diseases

LL Sun, WD Li, FR Lei, XQ Li - Journal Of Cellular And …, 2018 - Wiley Online Library
Micro RNA s (mi RNA s) are small non‐coding RNA s that regulate gene expression at a
post‐transcriptional level via either the degradation or translational repression of a target …

Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model

K Jeong, YJ Yu, JY You, WJ Rhee, JA Kim - Lab on a Chip, 2020 - pubs.rsc.org
Non-small cell lung cancer (NSCLC) is one of the leading causes of death from cancer
worldwide. The delivery and controlled regulation of miRNAs via exosomes is known as a …

Anticancer effects of fucoxanthin through cell cycle arrest, apoptosis induction, angiogenesis inhibition, and autophagy modulation

SA Ahmed, P Mendonca, R Elhag… - International Journal of …, 2022 - mdpi.com
Cancer accounts for one in seven deaths worldwide and is the second leading cause of
death in the United States, after heart disease. One of the standard cancer treatments is …

Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia

P Gangadaran, RL Rajendran, HW Lee… - Journal of Controlled …, 2017 - Elsevier
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are potential
therapies for various diseases, but their angiogenic mechanisms of therapeutic efficacy …

Channeling the force: Piezo1 mechanotransduction in cancer metastasis

JA Dombroski, JM Hope, NS Sarna, MR King - Cells, 2021 - mdpi.com
Cancer metastasis is one of the leading causes of death worldwide, motivating research into
identifying new methods of preventing cancer metastasis. Recently there has been …

A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition

C Gong, O Milberg, B Wang, P Vicini… - Journal of the …, 2017 - royalsocietypublishing.org
When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as …

Anti-angiogenic vanadium pentoxide nanoparticles for the treatment of melanoma and their in vivo toxicity study

S Das, A Roy, AK Barui, MMA Alabbasi, M Kuncha… - Nanoscale, 2020 - pubs.rsc.org
In recent days, vanadium complexes and nanoparticles have received sustainable attention
owing to their vast applications in different fields. In the present study, we report a facile …

ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors

M Song, SD Finley - Cell Communication and Signaling, 2020 - Springer
Background Angiogenesis plays an important role in the survival of tissues, as blood vessels
provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is …

Spatiotemporal multi-scale modeling of radiopharmaceutical distributions in vascularized solid tumors

M Kiani Shahvandi, M Soltani, F Moradi Kashkooli… - Scientific reports, 2022 - nature.com
We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal
distributions within vascularized solid tumors. The novelty of the presented model is at …