Homologous recombination enables the cell to access and copy intact DNA sequence
information in trans, particularly to repair DNA damage affecting both strands of the double …

Summary Background Primary Ovarian Insufficiency (POI), a public health problem, affects 1-
3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are …

In eukaryotes, all DNA transactions happen in the context of chromatin that often takes part
in regulatory mechanisms. In particular, chromatin structure can regulate exchanges of DNA …

Meiosis is the developmental program that generates gametes. To produce healthy
gametes, meiotic recombination creates reciprocal exchanges between each pair of …

During homologous recombination, Rad51 forms a nucleoprotein filament on single-
stranded DNA to promote DNA strand exchange. This filament binds to double-stranded …

Homologous recombination (HR) is essential for maintaining genome stability. Although
Rad51 is the key protein that drives HR, multiple auxiliary factors interact with Rad51 to …

During homologous recombination, Rad51 forms a nucleoprotein filament with single-
stranded DNA (ssDNA) that undergoes strand exchange with homologous double-stranded …

Genetic interactions have long informed our understanding of the coordinated proteins and
pathways that respond to DNA damage in mammalian cells, but systematic interrogation of …

Eukaryotic Rad51 protein is essential for homologous-recombination repair of DNA double-
strand breaks. Rad51 recombinases first assemble onto single-stranded DNA to form a …

Interhomolog recombination in meiosis requires a meiosis-specific recombinase, Dmc1. In
Saccharomyces cerevisiae, the Mei5–Sae3 complex facilitates the loading of Dmc1 onto the …