Endothelial cells synthesize and release various factors that regulate angiogenesis,
inflammatory responses, hemostasis, as well as vascular tone and permeability. Endothelial …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

Peptides derived from proteolytic processing of the β–amyloid precursor protein (APP),
including the amyloid–β peptide, are important for the pathogenesis of Alzheimer's …

Increased intrahepatic resistance in cirrhotic livers is in part caused by increased vascular
tone. Several morphological abnormalities have been described in the sinusoidal …

Superoxide radical (O2−) is increased in the vessel wall of spontaneously hypertensive rats
(SHR) where its blockade potentiates endothelium-dependent vasodilation. The purpose of …

Background Hyperpolarization of vascular muscle in response to activation of potassium
channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different …

In the aorta of spontaneously hypertensive rats (SHR), the endothelial dysfunction is due to
the release of endothelium‐derived contracting factors (EDCFs) that counteract the …

We examined effects of NG, NG-dimethyl-L-arginine (asymmetric dimethylarginine, ADMA),
an endogenous inhibitor of nitric oxide (NO) synthase, on cerebral vascular responses using …

Using both in vitro and in vivo techniques, it has repeatedly been shown that endothelium-
dependent vasodilation (EDV) is impaired in different forms of experimental hypertension …

Cerebral blood flow is largely independent of perfusion pressure when autoregulation is
intact. Cerebral circulation is regulated mainly by changes of vascular resistance …