Biomarker development for axial spondyloarthritis

MA Brown, Z Li, KAL Cao - Nature Reviews Rheumatology, 2020 - nature.com
The term axial spondyloarthritis (axSpA) encompasses a heterogeneous group of diseases
that have variable presentations, extra-articular manifestations and clinical outcomes, and …

Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: a position paper from the EU-CardioRNA COST action CA17129

M Vanhaverbeke, R Attard, M Bartekova… - Cardiovascular …, 2022 - academic.oup.com
Despite significant advances in the diagnosis and treatment of cardiovascular diseases,
recent calls have emphasized the unmet need to improve precision-based approaches in …

Sexual dimorphism in the Th17 signature of ankylosing spondylitis

E Gracey, YC Yao, B Green, Z Qaiyum… - Arthritis & …, 2016 - Wiley Online Library
Objective To identify an immunologic basis for the male sex bias in ankylosing spondylitis
(AS). Methods Cohorts of male and female patients with AS and age‐and sex‐matched …

Upregulated of ANXA3, SORL1, and neutrophils may be key factors in the progressionof ankylosing spondylitis

J Jiang, X Zhan, H Qu, T Liang, H Li, L Chen… - Frontiers in …, 2022 - frontiersin.org
Introduction The specific pathogenesis of ankylosing spondylitis (AS) remains unclear, and
our study aimed to investigate the possible pathogenesis of AS. Materials and Methods Two …

Genetics and functional genomics of spondyloarthritis

F Costantino, M Breban, HJ Garchon - Frontiers in immunology, 2018 - frontiersin.org
Spondyloarthritis (SpA) is a chronic inflammatory disorder with high heritability but with
complex genetics. It encompasses several entities that share common clinical features. Most …

[HTML][HTML] Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

AC Brown, CJ Cohen, O Mielczarek, G Migliorini… - Cell Genomics, 2023 - cell.com
Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis
characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association …

Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors

KR Haynes, AR Pettit, R Duan, HW Tseng… - Arthritis research & …, 2012 - Springer
Introduction Ankylosing spondylitis (AS) is unique in its pathology where inflammation
commences at the entheses before progressing to an osteoproliferative phenotype …

Evaluation of DNMT1 gene expression profile and methylation of its promoter region in patients with ankylosing spondylitis

S Aslani, M Mahmoudi, M Garshasbi, AR Jamshidi… - Clinical …, 2016 - Springer
Ankylosing spondylitis (AS) is an autoimmune disease with a chronic inflammatory arthritis.
The critical role of methylation in the biology of immunocytes has increasingly been …

Identification of breast cancer mechanism based on weighted gene coexpression network analysis

X Guo, H Xiao, S Guo, L Dong, J Chen - Cancer gene therapy, 2017 - nature.com
Our gene expression-profiling analysis aimed to explain the mechanism of breast cancer
development by identifying key pathways and constructing networks of related transcription …

Single‐cell RNA‐seq reveals altered NK cell subsets and reduced levels of cytotoxic molecules in patients with ankylosing spondylitis

C Ren, M Li, Y Zheng, B Cai, W Du… - Journal of Cellular …, 2022 - Wiley Online Library
Ankylosing spondylitis (AS) is an autoimmune disease with unknown aetiology. To unravel
the mechanisms mediating AS pathogenesis, we profiled peripheral blood mononuclear …