[HTML][HTML] The melanocortin pathway and control of appetite-progress and therapeutic implications
G Baldini, KD Phelan - Journal of Endocrinology, 2019 - joe.bioscientifica.com
The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …
Metabolism and the circadian clock converge
K Eckel-Mahan, P Sassone-Corsi - Physiological reviews, 2013 - journals.physiology.org
Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …
from sleeping and waking to neurotransmitter secretion and cellular metabolism …
Roles of “wanting” and “liking” in motivating behavior: gambling, food, and drug addictions
MJF Robinson, AM Fischer, A Ahuja, EN Lesser… - Behavioral …, 2016 - Springer
The motivation to seek out and consume rewards has evolutionarily been driven by the urge
to fulfill physiological needs. However in a modern society dominated more by plenty than …
to fulfill physiological needs. However in a modern society dominated more by plenty than …
The link between stress and feeding behaviour
Exposure to stress is inevitable, and it may occur, to varying degrees, at different phases
throughout the lifespan. The impact of stress experienced in later life has been well …
throughout the lifespan. The impact of stress experienced in later life has been well …
Insulin dysregulation
N Frank, EM Tadros - Equine veterinary journal, 2014 - Wiley Online Library
Abnormalities of insulin metabolism include hyperinsulinaemia and insulin resistance, and
these problems are collectively referred to as insulin dysregulation in this review. Insulin …
these problems are collectively referred to as insulin dysregulation in this review. Insulin …
Feeding and reward: perspectives from three rat models of binge eating
RL Corwin, NM Avena, MM Boggiano - Physiology & behavior, 2011 - Elsevier
Research has focused on understanding how overeating can affect brain reward
mechanisms and subsequent behaviors, both preclinically and in clinical research settings …
mechanisms and subsequent behaviors, both preclinically and in clinical research settings …
Leptin resistance in diet‐induced obesity: the role of hypothalamic inflammation
KCG De Git, RAH Adan - Obesity reviews, 2015 - Wiley Online Library
The consumption of W estern diets, high in sugar and saturated fat, is a crucial contributor to
the alarming incidence of obesity and its associated morbidities. These diets have been …
the alarming incidence of obesity and its associated morbidities. These diets have been …
Obesity and insulin resistance: associations with chronic inflammation, genetic and epigenetic factors
A Gasmi, S Noor, A Menzel, L Pivina… - Current medicinal …, 2021 - ingentaconnect.com
Background: Obesity is known to be a multifactorial disease. In its pathogenesis, different
factors such as chronic inflammation, oxidative stress, insulin resistance, genetic factors …
factors such as chronic inflammation, oxidative stress, insulin resistance, genetic factors …
Ghrelin signalling and obesity: at the interface of stress, mood and food reward
H Schellekens, BC Finger, TG Dinan… - Pharmacology & …, 2012 - Elsevier
The neuronal circuitry underlying the complex relationship between stress, mood and food
intake are slowly being unravelled and several studies suggest a key role herein for the …
intake are slowly being unravelled and several studies suggest a key role herein for the …
Multiple roles for orexin/hypocretin in addiction
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …