Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …

Neuronal activity induces intracellular Ca2+ increase, which triggers activation of a series of
Ca2+‐dependent signaling cascades. Among these, the multifunctional Ca2+/calmodulin …

CaMKII is a major synaptic protein that is activated during the induction of long-term
potentiation (LTP) by the Ca 2+ influx through NMDARs. This activation is required for LTP …

Although it has been known for decades that hippocampal calcium/calmodulin (CaM)-
dependent protein kinase II (CaMKII) plays an essential role in learning and memory …

The abundant synaptic protein CaMKII is necessary for long-term potentiation (LTP) and
memory. However, whether CaMKII is required only during initial processes or whether it …

The most widely accepted view of memory in the brain holds that synapses are the storage
sites of memory, and that memories are formed through associative modification of …

Susceptibility to addictive behaviors has been related to both increases and decreases in
striatal function. Both profiles have been reported in humans as well as in animal models …

Natural and drug rewards act on the same neural pathway, the mesolimbic dopaminergic
system. In brain regions such as the nucleus accumbens and ventral tegmental area, drugs …

Memory involves the storage of information at synapses by an LTP-like process. This
information storage is synapse specific and can endure for years despite the turnover of all …

Successful addiction treatment depends on maintaining long-term abstinence, making
relapse prevention an essential therapeutic goal. However, exposure to environmental cues …