Amyloid fibrils have traditionally been considered only as pathological aggregates in human
neurodegenerative diseases, but it is increasingly becoming clear that the propensity to form …

One of the most important scientific discoveries of recent years was the disclosure that the
intestinal microflora takes part in bidirectional communication between the gut and the brain …

Background Alzheimer's disease (AD) prevalence is increasing, but its etiology remains
elusive. Gut microbes can contribute to AD pathology and may help identifying novel …

Objective We explore here a novel model for amyloidogenesis in Alzheimer's disease (AD).
This new perspective on AD amyloidosis seeks to provide a rational framework for …

The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …

Amyloid-ß (Aß) is best known as the misfolded peptide that is involved in the pathogenesis
of Alzheimer's disease (AD), and it is currently the primary therapeutic target in attempts to …

Alzheimer's disease (AD) is the primary cause of age-related dementia. Effective strategies
to prevent and treat AD remain elusive despite major efforts to understand its basic biology …

Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

Background Recently, we reported that patients with mild cognitive impairment (MCI) harbor
specific signature of bacteria in their gut and that a modified Mediterranean ketogenic diet …

The amyloid-β (Aβ) peptide has long been considered to be the driving force behind
Alzheimer's disease (AD). However, clinical trials that have successfully reduced Aβ burden …