The participation of extracellular vesicles in many cellular processes, including reproduction,
is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles …

The world's population will reach 10.4 billion in 2067, with 81% residing in Africa or Asia.
Arable land available for food production will decrease to 0.15 ha per person. Temperature …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …

More than a century ago, August Weissman defined a distinction between the germline
(responsible for propagating heritable information from generation to generation) and the …

The development of germ cells relies on contact and communication with neighboring
somatic cells that provide metabolic support and regulatory signals. In females, contact is …

STUDY QUESTION Are meiotic and developmental competence of human oocytes from
small (2–8 mm) antral follicles improved by applying an optimized IVM method involving a …

Significance: The precipitous age-related decline in female fertility is intimately associated
with a reduction in both the quantity and quality of the germline (oocytes). Although complex …

Assisted reproductive technologies in all mammals are critically dependent on the quality of
the oocytes used to produce embryos. For reasons not fully clear, oocytes matured in vitro …

The quality and maturation of an oocyte not only play decisive roles in fertilization and
embryo success, but also have long-term impacts on the later growth and development of …

Prior to ovulation, the mammalian oocyte undergoes a process of differentiation within the
ovarian follicle that confers on it the ability to give rise to an embryo. Differentiation …