Burden of disease and unmet needs in tuberous sclerosis complex with neurological manifestations: systematic review
L Hallett, T Foster, Z Liu, M Blieden… - … medical research and …, 2011 - Taylor & Francis
Objectives: Tuberous sclerosis complex (TSC) is a progressive genetic disorder
characterized by pervasive benign tumor growth. We sought to assess the current …
characterized by pervasive benign tumor growth. We sought to assess the current …
A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits
DM Feliciano, TV Lin, NW Hartman, CM Bartley… - International Journal of …, 2013 - Elsevier
Tuberous sclerosis complex (TSC) is an autosomal dominant monogenetic disorder that is
characterized by the formation of benign tumors in several organs as well as brain …
characterized by the formation of benign tumors in several organs as well as brain …
Centre of epileptogenic tubers generate and propagate seizures in tuberous sclerosis
Abstract See Duchowny (doi: 10.1093/aww216) for a scientific commentary on this article.
Multiple seizure foci, seizure propagation and epileptic spasms complicate presurgical …
Multiple seizure foci, seizure propagation and epileptic spasms complicate presurgical …
Surgery for drug‐resistant tuberous sclerosis complex‐associated epilepsy: who, when, and what
N Specchio, C Pepi, L de Palma, R Moavero… - Epileptic …, 2021 - Wiley Online Library
Objective: Tuberous sclerosis complex (TSC) is a multisystem genetic disorder associated
with refractory early‐onset epilepsy. Current evidence supports surgery as the intervention …
with refractory early‐onset epilepsy. Current evidence supports surgery as the intervention …
Single and staged laser interstitial thermal therapy ablation for cortical tubers causing refractory epilepsy in pediatric patients
Z Tovar-Spinoza, R Ziechmann, S Zyck - Neurosurgical focus, 2018 - thejns.org
OBJECTIVE Magnetic resonance–guided laser interstitial thermal therapy (MRgLITT) is a
novel, minimally invasive treatment for the surgical treatment of epilepsy. In this paper, the …
novel, minimally invasive treatment for the surgical treatment of epilepsy. In this paper, the …
Mechanism-based treatment in tuberous sclerosis complex
K Jülich, M Sahin - Pediatric neurology, 2014 - Elsevier
Background Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that affects
the brain in almost every patient. It is caused by a mutation in the TSC1 or TSC2 genes …
the brain in almost every patient. It is caused by a mutation in the TSC1 or TSC2 genes …
Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion
DM Feliciano, JL Quon, T Su, MM Taylor… - Human molecular …, 2012 - academic.oup.com
Neurological symptoms in tuberous sclerosis complex (TSC) and associated brain lesions
are thought to arise from abnormal embryonic neurogenesis due to inherited mutations in …
are thought to arise from abnormal embryonic neurogenesis due to inherited mutations in …
Neuroimaging in tuberous sclerosis complex
C Russo, A Nastro, D Cicala, M De Liso… - Child's Nervous …, 2020 - Springer
Introduction Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder
affecting multiple systems, due to inactivating mutations of TSC1 or TSC2 mTOR pathway …
affecting multiple systems, due to inactivating mutations of TSC1 or TSC2 mTOR pathway …
Genetic pathogenesis of the epileptogenic lesions in Tuberous Sclerosis Complex: Therapeutic targeting of the mTOR pathway
R Moavero, A Mühlebner, MJ Luinenburg, D Craiu… - Epilepsy & Behavior, 2022 - Elsevier
Tuberous sclerosis complex (TSC) is a genetic multisystem disease due to the mutation in
one of the two genes TSC1 and TSC2, affecting several organs and systems and carrying a …
one of the two genes TSC1 and TSC2, affecting several organs and systems and carrying a …
Current role of surgery for tuberous sclerosis complex-associated epilepsy
N Specchio, GC Pavia, L de Palma… - Pediatric …, 2022 - mednexus.org
Tuberous sclerosis complex (TSC) is a rare multisystem, autosomal dominant
neurocutaneous syndrome in which epilepsy is the most common of several neurological …
neurocutaneous syndrome in which epilepsy is the most common of several neurological …