PROTACs in the management of prostate cancer
P Yedla, AO Babalghith, VV Andra, R Syed - Molecules, 2023 - mdpi.com
Cancer treatments with targeted therapy have gained immense interest due to their low
levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have …
levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have …
Carbonic anhydrases: Moiety appended derivatives, medicinal and pharmacological implications
A Jaitak, K Kumari, S Kounder, V Monga - Bioorganic & Medicinal …, 2024 - Elsevier
In the realm of enzymology, Carbonic anhydrase (CA) emerges as a pivotal protagonist
orchestrating the rapid conversion of carbon dioxide and water into bicarbonate ions and …
orchestrating the rapid conversion of carbon dioxide and water into bicarbonate ions and …
Synthesis, characterization, molecular docking and in vitro anti-cancer activity studies of new and highly selective 1, 2, 3-triazole substituted 4-hydroxybenzohyrdazide …
In this study, 16 new hybrid compounds 6 (ah) and 7 (ah) were synthesized starting from
methylparaben. These new compounds consist of eight 1, 2, 3-triazole-arylidenehydrazide …
methylparaben. These new compounds consist of eight 1, 2, 3-triazole-arylidenehydrazide …
Synthesis, Characterization, Molecular Docking and in vitro Biological Studies of Thiazolidin‐4‐one Derivatives as Anti‐Breast‐Cancer Agents
In this study, 16 new compounds were synthesized starting from methylparaben. These new
compounds consist of eight arylidenehydrazide derivatives and eight thiazolidin‐4‐on …
compounds consist of eight arylidenehydrazide derivatives and eight thiazolidin‐4‐on …
A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular …
All the previously reported phenylpyrazoles as carbonic anhydrase inhibitors (CAIs) were
found to have small sizes and high levels of flexibility, and hence showed low selectivity …
found to have small sizes and high levels of flexibility, and hence showed low selectivity …
Potential health benefits of banana phenolic content during ripening by implementing analytical and in silico techniques
Banana ranks as the fifth most cultivated agricultural crop globally, highlighting its crucial
socio-economic role. The banana's health-promoting benefits are correlated with its …
socio-economic role. The banana's health-promoting benefits are correlated with its …
Synthesis, characterization, crystal structure, molecular docking, and biological studies of Cu, Ni and Co metal complexes of pyrazole
I Mahmudov, B Ibrahimova, P Taslimi… - Journal of Molecular …, 2024 - Elsevier
Utilizing ligands based on pyrazole synthesized some transition metal complexes. Selected
salts such as Co (CH 3 COO) 2· 4H 2 O, Ni (CH 3 COO) 2· 4H 2 O (in the presence of …
salts such as Co (CH 3 COO) 2· 4H 2 O, Ni (CH 3 COO) 2· 4H 2 O (in the presence of …
Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS
In the study, water, ethanol, methanol, dichloromethane, and acetone extracts of Asparagus
officinalis L. were obtained by maceration. DPPH⋅, ABTS⋅+, FRAP, and CUPRAC methods …
officinalis L. were obtained by maceration. DPPH⋅, ABTS⋅+, FRAP, and CUPRAC methods …
Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species
The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum
Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit. ex Willd., respectively …
Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit. ex Willd., respectively …
Peripheral (E)‐2‐[(4‐hydroxybenzylidene)‐3,4‐dihydronaphthalen‐1(2H)‐one)]‐coordinated phthalocyanines with improved enzyme inhibition properties and …
Abstract In this study,(E)‐4‐{4‐[(1‐oxo‐3, 4‐dihydronaphthalen‐2 (1H)‐ylidene) methyl]
phenoxy} phthalonitrile (4) and its phthalocyanine derivatives (5–8) were synthesized for the …
phenoxy} phthalonitrile (4) and its phthalocyanine derivatives (5–8) were synthesized for the …