Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …

The extracellular antagonists of the Wnt signalling pathway can be divided into two broad
classes. Both classes of molecule prevent ligand-receptor interactions, but by different …

WNT signalling has a key role in early embryonic patterning through the regulation of cell
fate decisions, tissue polarity and cell movements. In the nervous system, WNT signalling …

▪ Abstract TGFß signals belonging to the Nodal family set up the embryonic axes, induce
mesoderm and endoderm, pattern the nervous system, and determine left-right asymmetry in …

Abstract Dickkopf1 (Dkk1) is a secreted protein that acts as a Wnt inhibitor and, together with
BMP inhibitors, is able to induce the formation of ectopic heads in Xenopus. Here, we show …

The transforming growth factor-β (TGF-β) superfamily contains a variety of growth factors
which all share common sequence elements and structural motifs. These proteins are …

Heart induction in Xenopus occurs in paired regions of the dorsoanterior mesoderm in
response to signals from the Spemann organizer and underlying dorsoanterior endoderm …

The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity
of the mouse embryo, but the molecular nature of the signals required remains to be …

Abstract Development of the mammalian embryo begins with formation of the totipotent
zygote during fertilization. This initial cell is able to give rise to every embryonic tissue of the …

The Smad proteins are important intracellular mediators of the transforming growth factor β
(TGFβ) family of secreted growth factors. Smad1 is an effector of signals provided by the …