Abstract The multifunctional Survival Motor Neuron (SMN) protein is required for the survival
of all organisms of the animal kingdom. SMN impacts various aspects of RNA metabolism …

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by abnormally low
cellular levels of the ubiquitous protein SMN. Traditionally, reduced levels of SMN were …

Spinal muscular atrophy (SMA) results from reduced levels of the survival of motor neuron
(SMN) protein, which has a well characterized function in spliceosomal small nuclear …

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by homozygous
mutations or deletions in the survival of motor neuron (SMN1) gene, encoding the …

Spinal muscular atrophies (SMAs) are a group of inherited disorders characterized by motor
neuron loss in the spinal cord and lower brainstem, muscle weakness, and atrophy. The …

Spinal muscular atrophy, a hereditary degenerative disorder of lower motor neurons
associated with progressive muscle weakness and atrophy, is the most common genetic …

Objective: Spinal muscular atrophy (SMA) is the number 1 genetic killer of young children. It
is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. Although …

Reduced survival motor neuron (SMN) protein triggers the motor neuron disease, spinal
muscular atrophy (SMA). Restoring SMN prevents disease, but it is not known how …

Spinal muscular atrophy (SMA) is a common (∼ 1: 6400) autosomal recessive
neuromuscular disorder caused by a paucity of the survival of motor neuron (SMN) protein …

F-actin bundling plastin 3 (PLS3) is a fully protective modifier of the neuromuscular disease
spinal muscular atrophy (SMA), the most common genetic cause of infant death. The …