Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
[HTML][HTML] Dynamics and functions of lipid droplets
JA Olzmann, P Carvalho - Nature reviews Molecular cell biology, 2019 - nature.com
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
Enzymatic noncovalent synthesis
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
The assembly of lipid droplets and their roles in challenged cells
WM Henne, ML Reese, JM Goodman - The EMBO journal, 2018 - embopress.org
Cytoplasmic lipid droplets are important organelles in nearly every eukaryotic and some
prokaryotic cells. Storing and providing energy is their main function, but they do not work in …
prokaryotic cells. Storing and providing energy is their main function, but they do not work in …
Hepatic lipid droplet homeostasis and fatty liver disease
In cells, lipids are stored in lipid droplets, dynamic organelles that adapt their size,
abundance, lipid and protein composition and organelle interactions to metabolic changes …
abundance, lipid and protein composition and organelle interactions to metabolic changes …
[HTML][HTML] The biogenesis of lipid droplets: lipids take center stage
Lipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate
many aspects of cell physiology. However, our understanding of the biogenesis of LDs …
many aspects of cell physiology. However, our understanding of the biogenesis of LDs …
Architecture of lipid droplets in endoplasmic reticulum is determined by phospholipid intrinsic curvature
Lipid droplets (LDs) store fats and play critical roles in lipid and energy homeostasis. They
form between the leaflets of the endoplasmic reticulum (ER) membrane and consist of a …
form between the leaflets of the endoplasmic reticulum (ER) membrane and consist of a …
Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure
V Zoni, R Khaddaj, I Lukmantara… - Proceedings of the …, 2021 - National Acad Sciences
Lipid droplets (LDs) are intracellular organelles responsible for lipid storage, and they
emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly …
emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly …
Lipid droplet biogenesis
CL Jackson - Current opinion in cell biology, 2019 - Elsevier
Lipid droplets (LDs) store neutral lipids in their core as an energy source when nutrients are
scarce. The center of an LD is hydrophobic, and hence it is surrounded by a phospholipid …
scarce. The center of an LD is hydrophobic, and hence it is surrounded by a phospholipid …
Protein quality control and lipid droplet metabolism
MA Roberts, JA Olzmann - Annual review of cell and …, 2020 - annualreviews.org
Lipid droplets (LDs) are endoplasmic reticulum–derived organelles that consist of a core of
neutral lipids encircled by a phospholipid monolayer decorated with proteins. As hubs of …
neutral lipids encircled by a phospholipid monolayer decorated with proteins. As hubs of …