Non-structural protein 1 (Nsp1) is one of the first proteins produced during coronaviral
infections. It plays a pivotal role in hijacking and rendering the host gene expression under …

All betacoronaviruses (β-CoVs) encode non-structural protein 1 (Nsp1), an essential
pathogenicity factor that potently restricts host gene expression. Among the β-CoV family …

An important pathogenicity factor of SARS-CoV-2 and related coronaviruses is Non-
structural protein 1 (Nsp1), which suppresses host gene expression and stunts antiviral …

SARS-CoV-2 is the causative virus of the devastating COVID-19 pandemic that results in an
unparalleled global health and economic crisis. Despite unprecedented scientific efforts and …

Alphaviruses have been used as vectors for the expression of heterologous genetic
information for a few decades. Their genomes contain two open reading frames. One of …

ABSTRACT SARS-CoV-2, the causative agent of COVID-19, has been intensely studied in
search of effective antiviral treatments. The immunosuppressant cyclosporine A (CsA) has …

Following virus recognition of host cell receptors and viral particle/genome internalization,
viruses replicate in the host via hijacking essential host cell machinery components to evade …

The ongoing global threats posed by COVID‐19 pandemic, catalyzed by SARS‐CoV‐2,
underscores the pressing need for effective antiviral strategies. The viral non‐structural …

When host cells are infected with coronaviruses, the first viral protein produced is Nsp1. This
protein inhibits host protein synthesis and induces host mRNA degradation to enhance viral …

An important pathogenicity factor of SARS-CoV-2 and related coronaviruses is Nsp1, which
suppresses host gene expression and stunts antiviral signaling. SARS-CoV-2 Nsp1 binds …