Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential

X Xu, Q Peng, X Jiang, S Tan, Y Yang… - … & Molecular Medicine, 2023 - nature.com
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

The dark proteome: translation from noncanonical open reading frames

BW Wright, Z Yi, JS Weissman, J Chen - Trends in Cell Biology, 2022 - cell.com
Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …

Mitochondria-derived peptides in aging and healthspan

B Miller, SJ Kim, H Kumagai, K Yen… - The Journal of clinical …, 2022 - Am Soc Clin Investig
The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to
be studied, but one element has been unexplored: microproteins. Small open reading …

Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma

M Li, G Liu, X Jin, H Guo, S Setrerrahmane, X Xu, T Li… - Molecular cancer, 2022 - Springer
Background Although, micropeptides encoded by non-coding RNA have been shown to
have an important role in a variety of tumors processes, there have been no reports on …

Folate-modified carboxymethyl chitosan-based drug delivery system for breast cancer specific combination therapy via regulating mitochondrial calcium concentration

Y Lv, X Chen, Y Shen - Carbohydrate Polymers, 2024 - Elsevier
Although various drug delivery systems that regulated Ca 2+ concentration has been
developed for tumor therapy, their application still presented significant challenges due to …

A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury

X Zheng, M Wang, S Liu, H Chen, Y Li, F Yuan… - Cell Death & …, 2023 - nature.com
As a common pathology of many ocular disorders such as diabetic retinopathy and
glaucoma, retinal ischemia/reperfusion (IR) triggers inflammation and microglia activation …

Hypoxia-Responsive lncRNA AC115619 Encodes a Micropeptide That Suppresses m6A Modifications and Hepatocellular Carcinoma Progression

Q Zhang, T Wei, L Yan, S Zhu, W Jin, Y Bai, Y Zeng… - Cancer Research, 2023 - AACR
Long noncoding RNAs (lncRNA) regulate a number of aspects of cancer biology. Recent
research has shown that lncRNAs can encode micropeptides that mediate their functions in …

Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE

B Miller, SJ Kim, HH Mehta, K Cao, H Kumagai… - Molecular …, 2023 - nature.com
Mitochondrial DNA variants have previously associated with disease, but the underlying
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …

Cancer-related micropeptides encoded by ncRNAs: Promising drug targets and prognostic biomarkers

S Setrerrahmane, M Li, A Zoghbi, X Lv, S Zhang… - Cancer letters, 2022 - Elsevier
An exciting emerging topic in the noncoding RNA (ncRNA) field is the discovery of short
peptides called micropeptides (≤ 100 amino acids), whose novel therapeutic opportunities …

Microproteins: overlooked regulators of physiology and disease

KR Hassel, O Brito-Estrada, CA Makarewich - Iscience, 2023 - cell.com
Ongoing efforts to generate a complete and accurate annotation of the genome have
revealed a significant blind spot for small proteins (< 100 amino acids) originating from short …