The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
Cardiovascular disease and thrombosis in HIV infection
MV Perkins, SB Joseph, DP Dittmer… - … , and vascular biology, 2023 - Am Heart Assoc
HIV infection has transitioned from an acute, fatal disease to a chronic one managed by
antiretroviral therapy. Thus, the aging population of people living with HIV (PLWH) continues …
antiretroviral therapy. Thus, the aging population of people living with HIV (PLWH) continues …
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
NF McMyn, J Varriale, EJ Fray… - The Journal of …, 2023 - Am Soc Clin Investig
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of
treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in …
treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in …
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection
M Pardons, AE Baxter, M Massanella… - PLoS …, 2019 - journals.plos.org
The phenotypic characterization of the cells in which HIV persists during antiretroviral
therapy (ART) remains technically challenging. We developed a simple flow cytometry …
therapy (ART) remains technically challenging. We developed a simple flow cytometry …
The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation
MR Abrahams, SB Joseph, N Garrett, L Tyers… - Science translational …, 2019 - science.org
Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting
B Julg, L Dee, J Ananworanich, DH Barouch, K Bar… - The lancet HIV, 2019 - thelancet.com
Analytical antiretroviral treatment interruption (ATI) is an important feature of HIV research,
seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) …
seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) …
In vivo dynamics of the latent reservoir for HIV-1: new insights and implications for cure
JD Siliciano, RF Siliciano - Annual Review of Pathology …, 2022 - annualreviews.org
Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …
Why and where an HIV cure is needed and how it might be achieved
Despite considerable global investment, only 60% of people who live with HIV currently
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
The State of the HIV Epidemic in the Philippines: Progress and Challenges in 2023
LMA Gangcuangco, PC Eustaquio - Tropical Medicine and Infectious …, 2023 - mdpi.com
In the past decade, the Philippines has gained notoriety as the country with the fastest-
growing human immunodeficiency virus (HIV) epidemic in the Western Pacific region. While …
growing human immunodeficiency virus (HIV) epidemic in the Western Pacific region. While …