Predictive monitoring for early detection of sepsis in neonatal ICU patients

KD Fairchild - Current opinion in pediatrics, 2013 - journals.lww.com
Predictive monitoring for early detection of sepsis in neona... : Current Opinion in Pediatrics
Predictive monitoring for early detection of sepsis in neonatal ICU patients : Current Opinion …

In silico modeling: methods and applications to trauma and sepsis

Y Vodovotz, TR Billiar - Critical care medicine, 2013 - journals.lww.com
Objectives: To familiarize clinicians with advances in computational disease modeling
applied to trauma and sepsis. Data Sources: PubMed search and review of relevant medical …

Light entrainment of the SCN circadian clock and implications for personalized alterations of corticosterone rhythms in shift work and jet lag

Y Li, IP Androulakis - Scientific reports, 2021 - nature.com
The suprachiasmatic nucleus (SCN) functions as the central pacemaker aligning
physiological and behavioral oscillations to day/night (activity/inactivity) transitions. The light …

Allostatic adaptation and personalized physiological trade-offs in the circadian regulation of the HPA axis: A mathematical modeling approach

R Rao, IP Androulakis - Scientific reports, 2019 - nature.com
The hypothalamic-pituitary-adrenal (HPA) axis orchestrates the physiological response to
unpredictable acute stressors. Moreover, the HPA axis exhibits prominent circadian activity …

[HTML][HTML] A multiscale inflammatory map: linking individual stress to societal dysfunction

Y Vodovotz, J Arciero, PFMJ Verschure… - Frontiers in Science, 2024 - frontiersin.org
As populations worldwide show increasing levels of stress, understanding emerging links
among stress, inflammation, cognition, and behavior is vital to human and planetary health …

Practical identifiability and uncertainty quantification of a pulsatile cardiovascular model

AD Marquis, A Arnold, C Dean-Bernhoft… - Mathematical …, 2018 - Elsevier
Mathematical models are essential tools to study how the cardiovascular system maintains
homeostasis. The utility of such models is limited by the accuracy of their predictions, which …

Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis

Y Li, IP Androulakis - Frontiers in Endocrinology, 2022 - frontiersin.org
The suprachiasmatic nucleus (SCN) synchronizes the physiological rhythms to the external
light-dark cycle and tunes the dynamics of circadian rhythms to photoperiod fluctuations …

Removal of Inflammatory Ascites Is Associated With Dynamic Modification of Local and Systemic Inflammation Along With Prevention of Acute Lung Injury: In Vivo: and …

B Emr, D Sadowsky, N Azhar, LA Gatto, G An… - Shock, 2014 - journals.lww.com
Background: Sepsis-induced inflammation in the gut/peritoneal compartment occurs early in
sepsis and can lead to acute lung injury (ALI). We have suggested that inflammatory ascites …

Proposed mechanisms of relative bradycardia

F Ye, D Winchester, C Stalvey, M Jansen, A Lee… - Medical hypotheses, 2018 - Elsevier
Relative bradycardia is the term used to describe the mechanism where there is dissociation
between pulse and temperature. This finding is important to recognize since it may provide …

Kölliker-Fuse nuclei regulate respiratory rhythm variability via a gain-control mechanism

RR Dhingra, M Dutschmann… - American Journal of …, 2017 - journals.physiology.org
Respiration varies from breath to breath. On the millisecond timescale of spiking, neuronal
circuits exhibit variability due to the stochastic properties of ion channels and synapses …