Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-
associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl …

Rapid proliferation is a hallmark of cancer associated with sensitivity to therapeutics that
cause DNA replication stress (RS). Many tumors exhibit drug resistance, however, via …

Abstract Poly (ADP-ribosyl) ation (PARylation) is a widespread and highly conserved post-
translational modification catalysed by a large family of enzymes called poly (ADP-ribose) …

Cellular mechanisms that safeguard genome integrity are often subverted in cancer. To
identify cancer-related genome caretakers, we employed a convergent multi-screening …

Abstract Inactivation of SMARCA4/BRG1, the core ATPase subunit of mammalian SWI/SNF
complexes, occurs at very high frequencies in non–small cell lung cancers (NSCLC). There …

The DNA damage response (DDR) is a complex signaling network that relies on cascades
of protein phosphorylation, which are initiated by three protein kinases of the family of PI3 …

Accumulating evidence suggests mitochondria as key modulators of normal and premature
aging, yet whether primary oxidative phosphorylation (OXPHOS) deficiency can cause …

The DNA damage response (DDR) is an extensive signaling network that is robustly
mobilized by DNA double-strand breaks (DSBs). The primary transducer of the DSB …

The splicing factor RNA-binding motif protein 10 (RBM10) is frequently mutated in lung
adenocarcinoma (LUAD)(9-25%). Most RBM10 cancer mutations are loss-of-function …

Processive exoribonucleases are executors of RNA decay. In humans, their physical but not
functional interactions were thoughtfully investigated. Here we have screened cells deficient …