Cancers are supported by a distinct type of connective tissue stroma, crucial for tumor
survival and advancement. Hyaluronan is a major matrix molecule in the stroma of many …

Exciting studies involving the molecular regulation of lymphangiogenesis in lymphatic-
associated disorders (eg, wound healing, lymphedema and tumor metastasis) have focused …

The extracellular polysaccharide hyaluronan (HA) controls cell migration, differentiation and
proliferation, and contributes to the invasiveness of human cancers. In order to investigate …

Over the years, the manipulation and clinical application of drug-delivery nanosystems for
cancer diseases have attracted a rapid growth of academic research interests, and some …

Cancer is one of the leading noncommunicable diseases that vastly impacts both developed
and developing countries. Truly innovative diagnostics that inform disease susceptibility …

Toll-like receptors (TLRs) have raised an extraordinary interest in cancer research due to
their role in tumor progression. By activating the production of several biological factors …

Background Lymphatic and/or blood vessel tumoral invasion (LBVI) is a common
histopathologic finding of gastric carcinomas, which could make it an additional cost efficient …

Purpose Hyaluronan (HA), an extracellular and peri-cellular glycosaminoglycan with a large
molecular weight, plays an important role in cancer growth and metastasis. The aim of this …

In this study, we developed bio-stimuli-responsive multi-scale hyaluronic acid (HA)
nanoparticles encapsulated with polyamidoamine (PAMAM) dendrimers as the subunits …

BACKGROUND: Early diagnosis of patients with upper gastrointestinal cancer is important
because many cases are diagnosed in advanced stages and have poor prognosis. Several …