1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

At last count, nearly 5000 halogenated natural products have been discovered. In
approximately half of these compounds, the carbon atom to which the halogen is bound is …

The enantioselective production of compounds is a central theme in current research. The
broad utility of synthetic chiral molecules as single-enantiomer pharmaceuticals, in …

Chiral, metal-free Brønsted bases have been demonstrated capable of catalyzing several
types of C–C and C–X bond-forming reactions with high chemical and stereochemical …

This Minireview discusses the progress made in developing reactions where an olefin is
subjected to an asymmetric halogenation. It aims to serve as a reference for the studies …

Asymmetry is ubiquitous in every part of Nature1 and has a great impact in many fields, not
only in chemistry but also even in arts. In the pharmaceutical area, asymmetry plays an …

Treatment of α, α-dichloroaldehydes with various phenols in the presence of chiral triazolium
salt catalysts and excess base results in the synthesis of α-chloro aryl esters in good yield …

Over the last 40 years, research strategies in the field of asymmetric catalysis have been
founded upon the direct production of enantioenriched synthons which typically exist within …

For over a century, ketenes have intrigued organic chemists with their unusual physical
properties and unique spectrum of chemical reactivity; it is not an exaggeration to say that …