Objective The aim of our study was to test whether ketamine produces an antidepressant
effect in animal model of olfactory bulbectomy and assess the role of mammalian target of …

Depression is a psychiatric disorder characterized by a marked decrease in reward
sensitivity. By using the olfactory bulbectomy (OBX) model of depression, it was shown that …

Depression is the most common form of mental disability in the world. Depressive episodes
may be precipitated by severe acute stressful events or by mild chronic stressors. Studies on …

One of the aspects of Alzheimer disease is loss of cholinergic neurons in the basal forebrain,
which leads to development of cognitive impairment. Here, we used a model of cholinergic …

The olfactory bulbectomy (OBX) is a well-known method inducing animal model of
depression. Depression is associated with dysfunction of serotonin (5-hydroxytryptamine, 5 …

The aim of the present study was to explore the anti‑cancer effects of total flavonoids (TF) on
lung cancer and to investigate the underlying mechanism. The inhibitory effect of TF on the …

Extensive evidence indicates that noradrenergic activation is essentially involved in
mediating the enhancing effects of emotional arousal on memory consolidation. Our current …

Cognitive impairment is present in patients with depression. We hypothesized that alpha-
lipoic acid (ALA) can reduce cognitive impairment, especially when combined to …

Degeneration of septal cholinergic neurons caused by the immunotoxin 192IgG-saporin
(SAP) is a model of the pathological state that occurs in Alzheimer's disease. We studied …

Although depression-induced altered pain perception has been described in several
laboratory and clinical studies, its neurobiological mechanism in the central nervous system …