SCF-dependent proteolysis was first discovered via genetic screening of budding yeast
almost 25 years ago. In recent years, more and more functions of SCF (Skp1-Cullin 1-F-box) …

A dynamic proteome is required for cellular adaption to changing environments including
levels of O 2, and the SKP1/CULLIN-1/F-box protein/RBX1 (SCF) family of E3 ubiquitin …

The synaptonemal complex (SC) is a zipper-like protein assembly that links homologous
chromosomes to regulate recombination and segregation during meiosis. The SC has been …

Abstract Skp1 (S-phase kinase-associated protein 1-Homo sapiens) is an adapter protein of
the SCF (Skp1-Cullin1-Fbox) complex, which links the constant components (Cul1-RBX) …

E3-SCF (Skp1/cullin-1/F-box protein) polyubiquitin ligases activate the proteasomal
degradation of over a thousand proteins, but the evolutionary diversification of the F-box …

In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that
regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist …

The synaptonemal complex (SC) is a meiotic interface that assembles between parental
chromosomes and is essential for gamete formation. While the dimensions and …

Once considered unusual, nucleocytoplasmic glycosylation is now recognized as a
conserved feature of eukaryotes. While in animals, O-GlcNAc transferase (OGT) modifies …

The synaptonemal complex (SC) is a meiotic interface that assembles between parental
chromosomes and is essential for the formation of gametes. While the dimensions and …

Bacterial protein degradation is a regulated process aided by protease adaptors that alter
specificity of energy-dependent proteases. In Caulobacter crescentus, cell cycle–dependent …