A comparative view of metabolite and substrate stress and tolerance in microbial bioprocessing: from biofuels and chemicals, to biocatalysis and bioremediation

SA Nicolaou, SM Gaida, ET Papoutsakis - Metabolic engineering, 2010 - Elsevier
Metabolites, substrates and substrate impurities may be toxic to cells by damaging biological
molecules, organelles, membranes or disrupting biological processes. Chemical stress is …

Transcriptional regulation of nonfermentable carbon utilization in budding yeast

B Turcotte, XB Liang, F Robert… - FEMS yeast …, 2009 - academic.oup.com
Saccharomyces cerevisiae preferentially uses glucose as a carbon source, but following its
depletion, it can utilize a wide variety of other carbons including nonfermentable compounds …

Fatty acids production from hydrogen and carbon dioxide by mixed culture in the membrane biofilm reactor

F Zhang, J Ding, Y Zhang, M Chen, ZW Ding… - Water research, 2013 - Elsevier
Gasification of waste to syngas (H 2/CO 2) is seen as a promising route to a circular
economy. Biological conversion of the gaseous compounds into a liquid fuel or chemical …

Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Nicotiana benthamiana and Saccharomyces cerevisiae

T Gülck, JK Booth, Â Carvalho… - Journal of Natural …, 2020 - ACS Publications
Phytocannabinoids are a group of plant-derived metabolites that display a wide range of
psychoactive as well as health-promoting effects. The production of pharmaceutically …

The Path to Triacylglyceride Obesity in the sta6 Strain of Chlamydomonas reinhardtii

U Goodenough, I Blaby, D Casero, SD Gallaher… - Eukaryotic …, 2014 - Am Soc Microbiol
When the sta6 (starch-null) strain of the green microalga Chlamydomonas reinhardtii is
nitrogen starved in acetate and then “boosted” after 2 days with additional acetate, the cells …

[HTML][HTML] Mechanisms underlying lactic acid tolerance and its influence on lactic acid production in Saccharomyces cerevisiae

A Peetermans, MR Foulquié-Moreno… - Microbial Cell, 2021 - ncbi.nlm.nih.gov
One of the major bottlenecks in lactic acid production using microbial fermentation is the
detrimental influence lactic acid accumulation poses on the lactic acid producing cells. The …

Quantitative analysis of the modes of growth inhibition by weak organic acids in Saccharomyces cerevisiae

A Ullah, R Orij, S Brul, GJ Smits - Applied and environmental …, 2012 - Am Soc Microbiol
Weak organic acids are naturally occurring compounds that are commercially used as
preservatives in the food and beverage industries. They extend the shelf life of food products …

Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

R Pereira, Y Wei, E Mohamed, M Radi, C Malina… - Metabolic …, 2019 - Elsevier
Improving the growth phenotypes of microbes in high product concentrations is an essential
design objective in the development of robust cell factories. However, the limited knowledge …

Recent advances and challenges in the bioconversion of acetate to value-added chemicals

S Mutyala, JR Kim - Bioresource Technology, 2022 - Elsevier
Acetate is a major byproduct of the bioconversion of the greenhouse gas carbon dioxide,
pretreatment of lignocellulose biomass, and microbial fermentation. The utilization and …

Metabolic engineering of Saccharomyces cerevisiae for production of carboxylic acids: current status and challenges

DA Abbott, RM Zelle, JT Pronk… - FEMS yeast …, 2009 - academic.oup.com
To meet the demands of future generations for chemicals and energy and to reduce the
environmental footprint of the chemical industry, alternatives for petrochemistry are required …