Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

Glycans are critical to every facet of biology and medicine, from viral infections to
embryogenesis. Tools to study glycans are rapidly evolving; however, the majority of our …

Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play
important roles in many physiological and pathological processes. EVs enable intercellular …

This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …

Tumour growth is accompanied by tumour evasion of the immune system, a process that is
facilitated by immune checkpoint molecules such as programmed cell death protein 1 (PD1) …

Refractory metastatic rhabdomyosarcoma is largely incurable. Here we analyze the
response of a child with refractory bone marrow metastatic rhabdomyosarcoma to …

Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1
immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a …

Early cancer diagnosis is critical for improving patient survival and mortality rates, but most
diagnostics on solid tumors rely on imaging tests with limited sensitivity and specificity to …

Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in
tumour progression from malignant transformation to metastasis and immune evasion. One …