Mesenchymal stem cell-derived exosomes: applications in regenerative medicine

MD Hade, CN Suire, Z Suo - Cells, 2021 - mdpi.com
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …

Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Recent developments in isolating methods for exosomes

J Gao, A Li, J Hu, L Feng, L Liu, Z Shen - Frontiers in bioengineering …, 2023 - frontiersin.org
Exosomes are the smallest extracellular vesicles that can be released by practically all cell
types, and range in size from 30 nm to 150 nm. As the major marker of liquid biopsies …

Scaled preparation of extracellular vesicles from conditioned media

S Staubach, FN Bauer, T Tertel, V Börger… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) especially of mesenchymal stem/stomal cells (MSCs) are
increasingly considered as biotherapeutic agents for a variety of different diseases. For …

Matrix vesicles as a therapeutic target for vascular calcification

T Li, H Yu, D Zhang, T Feng, M Miao, J Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Vascular calcification (VC) is linked to an increased risk of heart disease, stroke, and
atherosclerotic plaque rupture. It is a cell-active process regulated by vascular cells rather …

Comprehensive review of MS‐based studies on N‐glycoproteome and N‐glycome of extracellular vesicles

Y Li, J Wang, W Chen, H Lu, Y Zhang - Proteomics, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayer‐enclosed particles that can be released by all
type of cells. Whereas, as one of the most common post‐translational modifications …

Manufacture of extracellular vesicles derived from mesenchymal stromal cells

PMP Lins, E Pirlet, M Szymonik, A Bronckaers… - Trends in …, 2023 - cell.com
Mesenchymal stromal cells (MSCs) are a promising therapy for various diseases ranging
from ischemic stroke to wound healing and cancer. Their therapeutic effects are mainly …

Advancements and insights in exosome-based therapies for wound healing: a comprehensive systematic review (2018–June 2023)

P Sousa, B Lopes, AC Sousa, A Moreira, A Coelho… - Biomedicines, 2023 - mdpi.com
Exosomes have shown promising potential as a therapeutic approach for wound healing.
Nevertheless, the translation from experimental studies to commercially available treatments …

Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?

ZY Feng, QY Zhang, J Tan, HQ Xie - Science China Life sciences, 2022 - Springer
Exosomes are nano-scale extracellular vesicles secreted by cells and constitute an
important part in the cell-cell communication. The main contents of the exosomes include …

GMP‐compliant manufacturing of biologically active cell‐derived vesicles produced by extrusion technology

HC Lau, DW Han, J Park, E Lehner… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) released by a variety of cell types have been shown to act as a
natural delivery system for bioactive molecules such as RNAs and proteins. EV therapy …