Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years

JFR Paton, BH Machado, DJA Moraes… - The Journal of …, 2022 - Wiley Online Library
Twenty‐five years ago, a new physiological preparation called the working heart–brainstem
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …

A narrative review of the mechanisms and consequences of intermittent hypoxia and the role of advanced analytic techniques in pediatric autonomic disorders

JM Ramirez, MS Carroll, N Burgraff, CM Rand… - Clinical Autonomic …, 2023 - Springer
Disorders of autonomic functions are typically characterized by disturbances in multiple
organ systems. These disturbances are often comorbidities of common and rare diseases …

PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

C Menuet, AA Connelly, JK Bassi, MR Melo, S Le… - Elife, 2020 - elifesciences.org
Heart rate and blood pressure oscillate in phase with respiratory activity. A component of
these oscillations is generated centrally, with respiratory neurons entraining the activity of …

Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs

EF Lucking, KM O'Connor, CR Strain, F Fouhy… - …, 2018 - thelancet.com
Background Carotid body (peripheral oxygen sensor) sensitisation is pivotal in the
development of chronic intermittent hypoxia (CIH)-induced hypertension. We sought to …

Analysis of respiratory sinus arrhythmia and directed information flow between brain and body indicate different management strategies of fMRI-related anxiety

B Rassler, K Blinowska, M Kaminski, G Pfurtscheller - Biomedicines, 2023 - mdpi.com
Background: Respiratory sinus arrhythmia (RSA) denotes decrease of cardiac beat-to-beat
intervals (RRI) during inspiration and RRI increase during expiration, but an inverse pattern …

Putting back respiration into respiratory sinus arrhythmia or high-frequency heart rate variability: Implications for interpretation, respiratory rhythmicity, and health

T Ritz - Biological Psychology, 2023 - Elsevier
Research on respiratory sinus arrhythmia, or high-frequency heart rate variability (its
frequency-domain equivalent), has been popular in psychology and the behavioral sciences …

Commonalities and differences in carotid body dysfunction in hypertension and heart failure

ISA Felippe, RD Río, H Schultz… - The Journal of …, 2023 - Wiley Online Library
Carotid body pathophysiology is associated with many cardiovascular–respiratory–
metabolic diseases. This pathophysiology reflects both hyper‐sensitivity and hyper‐tonicity …

Sleep biology updates: hemodynamic and autonomic control in sleep disorders

R Tamisier, JW Weiss, JL Pépin - Metabolism, 2018 - Elsevier
Sleep disorders like obstructive sleep apnea syndrome, periodic limb movements in sleep
syndrome, insomnia and narcolepsy-cataplexy are all associated with an increased risk of …

Cerebrovascular function in hypertension: Does high blood pressure make you old?

JR Jennings, MF Muldoon, B Allen, AT Ginty… - …, 2021 - Wiley Online Library
The majority of individuals over an age of 60 have hypertension. Elevated blood pressure
and older age are associated with very similar changes in brain structure and function. We …

C1 neurons are part of the circuitry that recruits active expiration in response to the activation of peripheral chemoreceptors

MR Malheiros-Lima, JN Silva, FC Souza, AC Takakura… - Elife, 2020 - elifesciences.org
Breathing results from the interaction of two distinct oscillators: the pre-Bötzinger Complex
(preBötC), which drives inspiration; and the lateral parafacial region (pFRG), which drives …