Development and challenges of antimicrobial peptides for therapeutic applications
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
Peptide design principles for antimicrobial applications
The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …
global health problem and highlights the need for novel anti-infective therapies …
[HTML][HTML] Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …
Membrane active antimicrobial peptides: translating mechanistic insights to design
J Li, JJ Koh, S Liu, R Lakshminarayanan… - Frontiers in …, 2017 - frontiersin.org
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …
Molecular dynamics simulations of membrane permeability
This Review illustrates the evaluation of permeability of lipid membranes from molecular
dynamics (MD) simulation primarily using water and oxygen as examples. Membrane …
dynamics (MD) simulation primarily using water and oxygen as examples. Membrane …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Advancements in antimicrobial nanoscale materials and self-assembling systems
Antimicrobial resistance is directly responsible for more deaths per year than either
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …
Mechanistic landscape of membrane-permeabilizing peptides
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
Antimicrobial peptides (AMPs): roles, functions and mechanism of action
R Seyfi, FA Kahaki, T Ebrahimi… - International Journal of …, 2020 - Springer
Antimicrobial peptides (AMPs) are a crucial part of innate immunity that exist in the most of
living organisms. In fact, AMPs have ability to incite the innate immune response and combat …
living organisms. In fact, AMPs have ability to incite the innate immune response and combat …
Recent developments on production, purification and biological activity of marine peptides
K Sridhar, BS Inbaraj, BH Chen - Food Research International, 2021 - Elsevier
Marine peptides are one of the richest sources of structurally diverse bioactive compounds
and a considerable attention has been drawn towards their production and bioactivity …
and a considerable attention has been drawn towards their production and bioactivity …