Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Background In patients with cirrhosis and spontaneous bacterial peritonitis, renal function
frequently becomes impaired. This impairment is probably related to a reduction in effective …

The gut and the liver are anatomically and physiologically connected, and this “gut–liver
axis” exerts various influences on liver pathology. The gut microbiota consists of various …

Models of liver fibrosis, which include cell culture models, explanted and biopsied human
material, and experimental animal models, have demonstrated that liver fibrosis is a highly …

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

The field of pancreatic stellate cell (PSC) biology is very young, as the essential invitro tools
to study these cells (ie, methods to isolate and culture PSC) were only developed as recently …

In 1876, von Kupffer described liver Sternzellen (star-shaped cells). The functions of these
cells remained enigmatic for 75 years until Ito observed lipid-containing perisinusoidal cells …