TGF-β Regulation of T Cells
WJ Chen - Annual review of immunology, 2023 - annualreviews.org
Transforming growth factor β (TGF-β) is a key cytokine regulating the development,
activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains …
activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains …
Repositioning TH cell polarization from single cytokines to complex help
S Tuzlak, AS Dejean, M Iannacone, FJ Quintana… - Nature …, 2021 - nature.com
When helper T (TH) cell polarization was initially described three decades ago, the TH cell
universe grew dramatically. New subsets were described based on their expression of few …
universe grew dramatically. New subsets were described based on their expression of few …
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes
The aryl-hydrocarbon receptor (AHR) is a ligand-activated transcription factor that buoys
intestinal immune responses. AHR induces its own negative regulator, the AHR repressor …
intestinal immune responses. AHR induces its own negative regulator, the AHR repressor …
The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease
V Rothhammer, FJ Quintana - Nature Reviews Immunology, 2019 - nature.com
The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …
processes in health and disease. However, our understanding of the molecular pathways …
Control of immunity by the microbiota
The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …
sites that are collectively known as the microbiota. It is increasingly clear that microbial …
Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?
H Hou, D Chen, K Zhang, W Zhang, T Liu, S Wang… - Cancer Letters, 2022 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. It involves the complex interactions between genetic …
cancer-related death worldwide. It involves the complex interactions between genetic …
Organoids in immunological research
YE Bar-Ephraim, K Kretzschmar… - Nature Reviews …, 2020 - nature.com
Much of our knowledge regarding the interactions between epithelial tissues and the
immune system has been gathered from animal models and co-cultures with cell lines …
immune system has been gathered from animal models and co-cultures with cell lines …
Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells
L Cervantes-Barragan, JN Chai, MD Tianero… - Science, 2017 - science.org
The small intestine contains CD4+ CD8αα+ double-positive intraepithelial lymphocytes (DP
IELs), which originate from intestinal CD4+ T cells through down-regulation of the …
IELs), which originate from intestinal CD4+ T cells through down-regulation of the …
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
INTRODUCTION There is a dimension to postnatal human development that involves
assembly of microbial communities in different body habitats, including the gut. Children with …
assembly of microbial communities in different body habitats, including the gut. Children with …
Gut microbial fatty acid isomerization modulates intraepithelial T cells
The human gut microbiome constantly converts natural products derived from the host and
diet into numerous bioactive metabolites,–. Dietary fats are essential micronutrients that …
diet into numerous bioactive metabolites,–. Dietary fats are essential micronutrients that …