As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

Amorphous solid dispersion (ASD) formulations are widely used for delivery of poorly
soluble drugs for dissolution enhancement and bioavailability improvement. When …

Highlights•Around half of the new molecular entities approved by the US Food and Drug
Administration are pharmaceutical salts.•The drug-approval database contains 61 …

With recent advances in the development of supersaturating oral dosage forms for poorly
water-soluble drugs, pharmaceutical scientists are increasingly applying in vitro dissolution …

Glass transition temperature (T g) is important for amorphous compounds because it can
have implications on their physical and chemical stability. With drugs that possess ionizable …

Amorphous solid dispersions (ASDs) are probably the most common and important
supersaturating drug delivery systems for the formulation of poorly water-soluble …

Twenty-five years ago, Hancock and Parks asked a provocative question:“what is the true
solubility advantage for amorphous pharmaceuticals?” Difficulties in determining the …

Abstract Formulation development for preclinical studies is an essential part of the drug
discovery and development process in that it enables pharmacokinetics, efficacy, and safety …

Formulations containing nanosized drug particles such as nanocrystals and nanosized
amorphous drug aggregates recently came into light as promising strategies to improve the …