The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

The culmination of decades of research on humanized mice is leading to advances in our
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity …

The efficient generation of hematopoietic stem cells from human pluripotent stem cells is
dependent on the appropriate specification of the definitive hematopoietic program during …

BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …

Transplantation of human embryonic stem cells (hESC) into immune-deficient mice leads to
the formation of differentiated tumors comprising all three germ layers, resembling …

The potential usefulness of human embryonic stem cells for therapy derives from their ability
to form any cell in the body. This potential has been used to justify intensive research …

Since the discovery of the “nude” mouse more than 40 years ago, investigators have
attempted to model human tumor growth in immunodeficient mice. Here, we summarize how …

In vitro generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells
(iPSCs) has the potential to provide novel therapeutic approaches for replacing bone …

Hemogenic endothelium (HE) has been recognized as a source of hematopoietic stem cells
(HSCs) in the embryo. Access to human HE progenitors (HEPs) is essential for enabling the …

Natural killer (NK) cells serve as important effectors for antitumor immunity, and CD56+
CD45+ NK cells can be routinely derived from human embryonic stem cells (hESCs) …