[HTML][HTML] Building and integrating brain-wide maps of nervous system function in invertebrates

TS Kramer, SW Flavell - Current Opinion in Neurobiology, 2024 - Elsevier
The selection and execution of context-appropriate behaviors is controlled by the integrated
action of neural circuits throughout the brain. However, how activity is coordinated across …

[HTML][HTML] Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale

U Dag, I Nwabudike, D Kang, MA Gomes, J Kim… - Cell, 2023 - cell.com
Serotonin influences many aspects of animal behavior. But how serotonin acts on its diverse
receptors across the brain to modulate global activity and behavior is unknown. Here, we …

[HTML][HTML] A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission

YC Huang, J Luo, W Huang, CM Baker, MA Gomes… - Current Biology, 2023 - cell.com
Animals generate a wide range of highly coordinated motor outputs, which allows them to
execute purposeful behaviors. Individual neurons in the circuits that generate behaviors …

A Markovian dynamics for Caenorhabditis elegans behavior across scales

AC Costa, T Ahamed, D Jordan… - Proceedings of the …, 2024 - pnas.org
How do we capture the breadth of behavior in animal movement, from rapid body twitches to
aging? Using high-resolution videos of the nematode worm Caenorhabditis elegans, we …

[HTML][HTML] Inhibitory feedback from the motor circuit gates mechanosensory processing in Caenorhabditis elegans

S Kumar, AK Sharma, A Tran, M Liu, AM Leifer - PLoS biology, 2023 - journals.plos.org
Animals must integrate sensory cues with their current behavioral context to generate a
suitable response. How this integration occurs is poorly understood. Previously, we …

The influence of emotion on temporal context models

LJ Lohnas, MW Howard - Cognition and Emotion, 2024 - Taylor & Francis
Temporal context models (TCMs) have been influential in understanding episodic memory
and its neural underpinnings. Recently, TCMs have been extended to explain emotional …

TWISP: a transgenic worm for interrogating signal propagation in Caenorhabditis elegans

AK Sharma, F Randi, S Kumar, S Dvali, AM Leifer - Genetics, 2024 - academic.oup.com
Genetically encoded optical indicators and actuators of neural activity allow for all-optical
investigations of signaling in the nervous system. But commonly used indicators, actuators …

[HTML][HTML] See Elegans: Simple-to-use, accurate, and automatic 3D detection of neural activity from densely packed neurons

E Lanza, V Lucente, M Nicoletti, S Schwartz, IF Cavallo… - Plos one, 2024 - journals.plos.org
In the emerging field of whole-brain imaging at single-cell resolution, which represents one
of the new frontiers to investigate the link between brain activity and behavior, the nematode …

A Markovian dynamics for C. elegans behavior across scales

AC Costa, T Ahamed, D Jordan, GJ Stephens - bioRxiv, 2023 - biorxiv.org
How do we capture the breadth of behavior in animal movement, from rapid body twitches to
aging? Using high-resolution videos of the nematode worm C. elegans, we show that a …

To reverse engineer an entire nervous system

G Haspel, ES Boyden, J Brown, G Church… - arXiv preprint arXiv …, 2023 - arxiv.org
There are many theories of how behavior may be controlled by neurons. Testing and
refining these theories would be greatly facilitated if we could correctly simulate an entire …