Manipulation of biological samples using micro and nano techniques

J Castillo, M Dimaki, WE Svendsen - Integrative Biology, 2009 - academic.oup.com
The constant interest in handling, integrating and understanding biological systems of
interest for the biomedical field, the pharmaceutical industry and the biomaterial researchers …

The ribosome modulates nascent protein folding

CM Kaiser, DH Goldman, JD Chodera, I Tinoco Jr… - Science, 2011 - science.org
Proteins are synthesized by the ribosome and generally must fold to become functionally
active. Although it is commonly assumed that the ribosome affects the folding process, this …

DNA sequencing by two-dimensional materials: As theoretical modeling meets experiments

L Liang, JW Shen, Z Zhang, Q Wang - Biosensors and Bioelectronics, 2017 - Elsevier
Owing to their extraordinary electrical, chemical, optical, mechanical and structural
properties, two-dimensional (2D) materials (mainly including graphene, boron nitride, MoS 2 …

Nanophotonic trapping for precise manipulation of biomolecular arrays

M Soltani, J Lin, RA Forties, JT Inman, SN Saraf… - Nature …, 2014 - nature.com
Optical trapping is a powerful manipulation and measurement technique widely used in the
biological and materials sciences,,,,,,,. Miniaturizing optical trap instruments onto optofluidic …

Single phage T4 DNA packaging motors exhibit large force generation, high velocity, and dynamic variability

DN Fuller, DM Raymer, VI Kottadiel… - Proceedings of the …, 2007 - National Acad Sciences
Terminase enzyme complexes, which facilitate ATP-driven DNA packaging in phages and in
many eukaryotic viruses, constitute a wide and potentially diverse family of molecular motors …

Measurements of single DNA molecule packaging dynamics in bacteriophage λ reveal high forces, high motor processivity, and capsid transformations

DN Fuller, DM Raymer, JP Rickgauer… - Journal of molecular …, 2007 - Elsevier
Molecular motors drive genome packaging into preformed procapsids in many double-
stranded (ds) DNA viruses. Here, we present optical tweezers measurements of single DNA …

[HTML][HTML] Characterization of photoactivated singlet oxygen damage in single-molecule optical trap experiments

MP Landry, PM McCall, Z Qi, YR Chemla - Biophysical journal, 2009 - cell.com
Optical traps or" tweezers" use high-power, near-infrared laser beams to manipulate and
apply forces to biological systems, ranging from individual molecules to cells. Although …

Ionic effects on viral DNA packaging and portal motor function in bacteriophage φ29

DN Fuller, JP Rickgauer, PJ Jardine… - Proceedings of the …, 2007 - National Acad Sciences
In many viruses, DNA is confined at such high density that its bending rigidity and
electrostatic self-repulsion present a strong energy barrier in viral assembly. Therefore, a …

[HTML][HTML] Portal motor velocity and internal force resisting viral DNA packaging in bacteriophage ϕ29

JP Rickgauer, DN Fuller, S Grimes, PJ Jardine… - Biophysical journal, 2008 - cell.com
During the assembly of many viruses, a powerful molecular motor compacts the genome into
a preassembled capsid. Here, we present measurements of viral DNA packaging in …

Nonequilibrium dynamics and ultraslow relaxation of confined DNA during viral packaging

ZT Berndsen, N Keller, S Grimes… - Proceedings of the …, 2014 - National Acad Sciences
Many viruses use molecular motors that generate large forces to package DNA to near-
crystalline densities inside preformed viral proheads. Besides being a key step in viral …