Manipulation of biological samples using micro and nano techniques
The constant interest in handling, integrating and understanding biological systems of
interest for the biomedical field, the pharmaceutical industry and the biomaterial researchers …
interest for the biomedical field, the pharmaceutical industry and the biomaterial researchers …
The ribosome modulates nascent protein folding
Proteins are synthesized by the ribosome and generally must fold to become functionally
active. Although it is commonly assumed that the ribosome affects the folding process, this …
active. Although it is commonly assumed that the ribosome affects the folding process, this …
DNA sequencing by two-dimensional materials: As theoretical modeling meets experiments
Owing to their extraordinary electrical, chemical, optical, mechanical and structural
properties, two-dimensional (2D) materials (mainly including graphene, boron nitride, MoS 2 …
properties, two-dimensional (2D) materials (mainly including graphene, boron nitride, MoS 2 …
Nanophotonic trapping for precise manipulation of biomolecular arrays
Optical trapping is a powerful manipulation and measurement technique widely used in the
biological and materials sciences,,,,,,,. Miniaturizing optical trap instruments onto optofluidic …
biological and materials sciences,,,,,,,. Miniaturizing optical trap instruments onto optofluidic …
Single phage T4 DNA packaging motors exhibit large force generation, high velocity, and dynamic variability
DN Fuller, DM Raymer, VI Kottadiel… - Proceedings of the …, 2007 - National Acad Sciences
Terminase enzyme complexes, which facilitate ATP-driven DNA packaging in phages and in
many eukaryotic viruses, constitute a wide and potentially diverse family of molecular motors …
many eukaryotic viruses, constitute a wide and potentially diverse family of molecular motors …
Measurements of single DNA molecule packaging dynamics in bacteriophage λ reveal high forces, high motor processivity, and capsid transformations
DN Fuller, DM Raymer, JP Rickgauer… - Journal of molecular …, 2007 - Elsevier
Molecular motors drive genome packaging into preformed procapsids in many double-
stranded (ds) DNA viruses. Here, we present optical tweezers measurements of single DNA …
stranded (ds) DNA viruses. Here, we present optical tweezers measurements of single DNA …
[HTML][HTML] Characterization of photoactivated singlet oxygen damage in single-molecule optical trap experiments
Optical traps or" tweezers" use high-power, near-infrared laser beams to manipulate and
apply forces to biological systems, ranging from individual molecules to cells. Although …
apply forces to biological systems, ranging from individual molecules to cells. Although …
Ionic effects on viral DNA packaging and portal motor function in bacteriophage φ29
DN Fuller, JP Rickgauer, PJ Jardine… - Proceedings of the …, 2007 - National Acad Sciences
In many viruses, DNA is confined at such high density that its bending rigidity and
electrostatic self-repulsion present a strong energy barrier in viral assembly. Therefore, a …
electrostatic self-repulsion present a strong energy barrier in viral assembly. Therefore, a …
[HTML][HTML] Portal motor velocity and internal force resisting viral DNA packaging in bacteriophage ϕ29
JP Rickgauer, DN Fuller, S Grimes, PJ Jardine… - Biophysical journal, 2008 - cell.com
During the assembly of many viruses, a powerful molecular motor compacts the genome into
a preassembled capsid. Here, we present measurements of viral DNA packaging in …
a preassembled capsid. Here, we present measurements of viral DNA packaging in …
Nonequilibrium dynamics and ultraslow relaxation of confined DNA during viral packaging
ZT Berndsen, N Keller, S Grimes… - Proceedings of the …, 2014 - National Acad Sciences
Many viruses use molecular motors that generate large forces to package DNA to near-
crystalline densities inside preformed viral proheads. Besides being a key step in viral …
crystalline densities inside preformed viral proheads. Besides being a key step in viral …