The Nr4a family of nuclear hormone receptors is composed of three members—
Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these …

The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that
are induced by various signals. They act as transcription factors and their activity is not …

Lactic acid has emerged as an important modulator of immune cell function. It can be
produced by both gut microbiota and the host metabolism at homeostasis and during …

Metabolic reprogramming is a vital hallmark of cancer, and it provides the necessary energy
and biological materials to support the continuous proliferation and survival of tumor cells …

The NR4A family of orphan nuclear receptors (Nr4a1–3) plays redundant roles to establish
and maintain Treg identity; deletion of multiple family members in the thymus results in Treg …

The nuclear receptor Nur77 is expressed in a multitude of tissues, regulating cell
differentiation and homeostasis. Dysregulation of Nur77 signaling is associated with cancer …

Pristane causes chronic peritoneal inflammation resulting in lupus, which in C57BL/6 mice is
complicated by lung microvascular injury and diffuse alveolar hemorrhage (DAH). Mineral …

Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is
also an essential repair mechanism to prevent cardiac rupture, signifying the importance of …

Nuclear receptor Nur77 plays a pivotal role in immune regulation across various tissues,
influencing pro-inflammatory signaling pathways and cellular metabolism. While cellular …

缺氧诱导因子与骨稳态失衡类疾病的相关性 Page 1 Chinese Journal of Tissue Engineering
Research|Vol 26|No.33|November 2022|5393 中国组织工程研究 Chinese Journal of Tissue …