Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging
DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints …

Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brain cancer with no
effective therapy. Histological similarity of DIPG to supratentorial high-grade astrocytomas of …

Childhood high-risk neuroblastomas with MYCN gene amplification are difficult to treat
effectively. This has focused attention on tumor-specific gene dependencies that underlie …

Truncating mutations in the terminal exon of protein phosphatase Mg2+/Mn2+ 1D (PPM1D)
have been identified in clonal hematopoiesis and myeloid neoplasms, with a striking …

The p53 transcription factor is a master regulator of cellular stress responses inhibited by
repressors such as MDM2 and the phosphatase PPM1D. Activation of p53 with …

Cellular stress-induced temporal alterations—ie, dynamics—are typically exemplified by the
dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially …

Protein tyrosine phosphatases (PTPs) superfamily catalyzes tyrosine de‐phosphorylation
which affects a myriad of cellular processes. Imbalance in signal pathways mediated by …

Darwinian evolution of tumor cells remains underexplored in childhood cancer. We here
reconstruct the evolutionary histories of 56 pediatric primary tumors, including 24 …

Simple Summary Neuroblastoma (NB) is the most frequent solid extracranial tumor in
children and the most frequently diagnosed cancer during infancy. A genetic modification, a …

A greater understanding of factors causing cancer initiation, progression and evolution is of
paramount importance. Among them, the serine/threonine phosphatase PPM1D, also …