Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies
GE Thorlacius, A Björk… - Nature Reviews …, 2023 - nature.com
In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …
Current and future therapies for primary Sjögren syndrome
R Seror, G Nocturne, X Mariette - Nature Reviews Rheumatology, 2021 - nature.com
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that is characterized by
a triad of symptoms that affect all patients (dryness, pain and fatigue). In addition, systemic …
a triad of symptoms that affect all patients (dryness, pain and fatigue). In addition, systemic …
Update on the pathophysiology and treatment of primary Sjögren syndrome
C Baldini, G Fulvio, G La Rocca, F Ferro - Nature Reviews …, 2024 - nature.com
Sjögren syndrome or Sjögren disease is a chronic form of autoimmune epithelitis
characterized by lymphocytic infiltration of the exocrine glands, particularly the salivary and …
characterized by lymphocytic infiltration of the exocrine glands, particularly the salivary and …
[HTML][HTML] A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren's syndrome
X Mariette, F Barone, C Baldini, H Bootsma, KL Clark… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND Primary Sjögren's syndrome (pSS) is characterized by B cell hyperactivity
and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (eg, belimumab) …
and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (eg, belimumab) …
Composite of Relevant Endpoints for Sjögren's Syndrome (CRESS): development and validation of a novel outcome measure
S Arends, L de Wolff, JF van Nimwegen… - The Lancet …, 2021 - thelancet.com
Background Recent randomised controlled trials (RCTs) in primary Sjögren's syndrome
used the European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease …
used the European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease …
CD8+ T Lymphocytes: Crucial Players in Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease associated with
damage to multiple organs and glands. The most common clinical manifestations are dry …
damage to multiple organs and glands. The most common clinical manifestations are dry …
Biological therapy in systemic lupus erythematosus, antiphospholipid syndrome, and Sjögren's syndrome: evidence-and practice-based guidance
A Marinho, J Delgado Alves, J Fortuna, R Faria… - Frontiers in …, 2023 - frontiersin.org
Systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and Sjögren's
syndrome (SS) are heterogeneous autoimmune diseases. Severe manifestations and …
syndrome (SS) are heterogeneous autoimmune diseases. Severe manifestations and …
Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a …
P Ruscitti, Y Allanore, C Baldini, G Barilaro… - Autoimmunity …, 2024 - Elsevier
Inflammatory rheumatic diseases are different pathologic conditions associated with a
deregulated immune response, codified along a spectrum of disorders, with …
deregulated immune response, codified along a spectrum of disorders, with …
The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome
Background While all salivary glands (SGs) can be involved in primary Sjögren's syndrome
(pSS), their respective role in pathogenesis remains unclear. Our objective was to assess …
(pSS), their respective role in pathogenesis remains unclear. Our objective was to assess …
Development and preliminary validation of the Sjögren's Tool for Assessing Response (STAR): a consensual composite score for assessing treatment effect in primary …
Objective To develop a composite responder index in primary Sjögren's syndrome (pSS):
the Sjögren's Tool for Assessing Response (STAR). Methods To develop STAR, the …
the Sjögren's Tool for Assessing Response (STAR). Methods To develop STAR, the …