Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

The past decade has witnessed a revival of interest in the hormone melatonin, partly
attributable to the discovery that genetic variation in MTNR1B–the melatonin receptor gene …

The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …

The circadian clock is an endogenous biological timekeeping system that synchronizes
physiology and behavior to day/night cycles. A wide variety of processes throughout the …

INTRODUCTION The circadian clock is a molecular oscillator that coordinates behavior and
physiology in anticipation of the daily light cycle. Desynchrony of circadian cycles, through …

Most living beings, including humans, must adapt to rhythmically occurring daily changes in
their environment that are generated by the E arth's rotation. In the course of evolution, these …

In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal
protein processing, oxidative stress and proinflammatory cytokines will drive the activation of …

The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …

The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …